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Posted: January 28th, 2022
MSN570 Week 2 Case Studies
A 47-year-old female presents with Stage IV breast cancer. Today, the PET scan reveals brain metastasis.
1. Define proliferation and differentiation and relate these changes to cancer.
2. Describe invasion, angiogenesis and metastasis.
3. There are three underlying causes of growth and maturity abnormalities: telamerase, pRB changes and 53 changes. Discuss these in relation to the patient.
4. Discuss tumor suppressor genes, oncogenes and DNA repair genes.
A 30-year-old presents with a history of IV drug use, HIV +, and is today diagnosed with pneumonia.
1. Does the patient have an acute or chronic state of inflammation? Explain the rationale.
2. What is the significance of cellular replication in a patient with HIV?
3. What is viral load and what is the relationship with CD4 T cells?
4. How did the pneumonia occur?
A 25-year-old male presents with chronic sinusitis and allergic rhinitis.
1. Define innate vs. acquired immunity.
2. Define active vs. passive immunity.
3. Discuss the genetic predisposition of allergens.
4. Describe the antigen-antibody response.
5. What is the pathology of sinusitis?
A 40-year-old has an endometrial biopsy report: benign endometrial hyperplasia.
1. Explain the diagnosis.
2. Which cells are implicated in this diagnosis? Compare and contrast atrophy vs. hyperplasia.
3. How does dysplasia differ from hyperplasia?
4. Does hyperplasia lead to neoplasia? Defend your answer.
Week 2 Case Studies in MSN570
The patient is a 47-year-old woman with Stage IV breast cancer. The PET scan today revealed brain metastases.
1. Explain what proliferation and differentiation are and how they relate to cancer.
2. Explain the concepts of invasion, angiogenesis, and metastasis.
3. Telamerase, pRB alterations, and 53 changes are the three fundamental causes of growth and maturity anomalies. Talk about them in terms of the patient.
4. Discuss tumor suppressor genes, oncogenes and DNA repair genes.
A 30-year-old woman presents with a history of IV drug use, is HIV positive, and has pneumonia.
1. Is the patient experiencing acute or chronic inflammation? Explain your reasoning.
2. What does cellular replication mean in the case of an HIV patient?
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