Top Research Professionals
The research experts and assignment help team consists exclusively of highly qualified graduate writers, each professional with in-depth subject matter expertise and significant experience in custom academic writing.
Boost Your Final Grades By Ordering Custom Writing Help!
For similar papers and sample answers; with a few clicks, Order your research paper, thesis, dissertation writing and other assignment help services
Posted: August 24th, 2022
Alpha1-antitrypsin (A1AT) deficiency is a relatively
Physiology homework help
Alpha1-antitrypsin (A1AT) deficiency is a relatively rare genetic disorder that causes affected individuals to have a predisposition to developing early signs of chronic obstructive pulmonary disorder (COPD), non-alcoholic cirrhosis of the liver, and in some cases, a skin disease called panniculitis. The most common cause of mortality in individuals with A1AT deficiency is emphysema, with liver disease following closely behind.
The disorder is due to defective alleles of the SERPINA1 gene, which encodes the A1AT protein. The protein’s normal physiological function is to act as a check on neutrophil elastase, an enzyme secreted by neutrophils in response to lung inflammation. The normal allele is denoted M. There are two mutant disease-causing alleles that are autosomal codominant: S and Z. Heterozygotes (MS and MZ) have a somewhat elevated risk of COPD, especially if they smoke; homozygous ZZ individuals have the most severe phenotype, with an extremely high risk of developing emphysema. M stands for the normal allele. There are two autosomal codominant mutant disease-causing alleles, S and Z, and they are both S and Z. Heterozygotes (MS and MZ) have a slightly higher chance of getting COPD, especially if they smoke. Homozygotes (ZZ) have the worst phenotype and have a very high chance of getting emphysema.
In many individuals with severe cases of A1AT deficiency (the ZZ genotype), intracellular accumulations in the liver are usually noted upon biopsy. What might be the cause of this phenomenon? What are the accumulations of, where in the cell would you expect to find them and why, and where do they come from? Hint… think about the normal physiological processes that occur within a cell, and how the defective A1AT protein arising from the Z allele might interfere with these processes.
Study Notes, Research Topics & Assignment Examples: Explain ways you might measure the future effects »Demographics and epidemiological transitions resultWhy Choose our Custom Writing Services
We prioritize delivering top quality work sought by college students.
Discounted Pricing
Our custom writing services maintain the highest quality while remaining affordable for students. Our pricing for research papers, theses, and dissertations is not only fair considering the superior quality but also competitive with other writing services.
0% Similarity Index
We guarantee plagiarism-free, human-written content. Every product is assured to be original and not AI-generated. Our writers, tutors and editors are research experts who ensures the right formating and citation sytles are followed. To note, all the final drafts undergo rigorous plagiarism checks before delivery for submission to ensure authenticity for our valued customers.
How it works
When you decide to place an order with Dissertation Help, here is what happens: